Brain Injury Impairs Working Memory and Prefrontal Circuit Function

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Brain Injury Impairs Working Memory and Prefrontal Circuit Function

More than 2.5 million Americans suffer a traumatic brain injury (TBI) each year. Even mild to moderate TBI causes long-lasting neurological effects. Despite its prevalence, no therapy currently exists to treat the underlying cause of cognitive impairment suffered by TBI patients. Following lateral fluid percussion injury (LFPI), the most widely used experimental model of TBI, we investigated al...

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The study on learning and memory is one of the striking subjects in neuroscience today. In the cerebral cortex, it is has been proved that, the hippocampus, the prefrontal cortex and the hippocampal-prefrontal cortical circuit are important to working memory. In this paper, we review findings of the anatomical and electrophysiological characteristics of the hippocampal-prefrontal cortical circu...

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This research was designed and conducted to compare the cognitive condition of two groups of healthy people and MTBI patients one year after their injury in terms of both executive functions and working memory.In this causal-comparative study, which was conducted from February 2017 to October 2018, two groups of individuals, 48(MTBI), male Patients from 30 to 55 years old who were admitted to t...

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ژورنال

عنوان ژورنال: Frontiers in Neurology

سال: 2015

ISSN: 1664-2295

DOI: 10.3389/fneur.2015.00240